Description

The 1921 Centre vs. Harvard football game was a regular-season collegiate American football game played on October 29, 1921, at Harvard Stadium in Boston, Massachusetts. The contest featured the undefeated Centre Praying Colonels, representing Centre College, and the undefeated Harvard Crimson, representing Harvard University. Centre won the game 6–0, despite entering as heavy underdogs, and the game is widely viewed as one of the largest upsets in college football history. The game is often referred to by the shorthand C6H0, after a Centre professor's remark that Harvard had been poisoned by this "impossible" chemical formula.